Therefore, the child does not have a properly working copy of the gene. In autosomal recessive forms, a child inherits a copy of a gene with a mutation from both parents. A person who has a recessive form of CMT is said to have a CMT Type 4. The least common forms of CMT in the United States are inherited in an autosomal recessive manner. In all autosomal dominant conditions, people affected with the condtion can pass the gene causing CMT to their children, but people without the condition do not have the abnormal gene in their DNA and thus cannot pass CMT on to their children. Boys or girls have an equal chance of inheriting the disease in this inheritance pattern and an equal chance of passing down the condition. An affected person has one gene with a mutation and one gene without a mutation in the relevant pair and each child has a 50/50 chance of inheriting the gene with the mutation, giving that person the disorder. Autosomal means that the mutation occurs on a chromosome other than the X or Y chromosome. The most common forms of CMT are inherited in an autosomal dominant pattern. There are three distinct inheritance patterns that encompass all the many variations of CMT. The many different forms of CMT are inherited in different ways, so genetic counseling will vary depending on your form of CMT and its mode of inheritance. Knowing which of the forms of CMT you have is important so that you can understand the implications for passing the disease on to your children.
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